Synthesis and Characterization of Gellan Gum-Pyridoxine Nanoparticle for Treatment of Localized Peripheral Neuropathy
Vigneshwaran R1, Sankar M2, Vigneshkumar S.3
1Vigneshwaran R, Department of Biotechnology, Kalasalingam Academy of Research and Education College, Krishnankoil (Tamil Nadu), India.
2Sankar M, Department of Biotechnology, Mepco Schlenk Engineering College, Sivakasi (Tamil Nadu), India.
3Vigneshkumar S, Department of Biotechnology, Mepco Schlenk Engineering College, Sivakasi (Tamil Nadu), India.
Manuscript received on 24 November 2019 | Revised Manuscript received on 18 December 2019 | Manuscript Published on 30 December 2019 | PP: 576-580 | Volume-9 Issue-1S4 December 2019 | Retrieval Number: A11271291S419/19©BEIESP | DOI: 10.35940/ijeat.A1127.1291S419
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© The Authors. Blue Eyes Intelligence Engineering and Sciences Publication (BEIESP). This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Abstract: Biopolymer has full application as a drug carrier and scaffold in tissue engineering because of its biodegradability and non-toxicity. The present study is focused on novel biopolymer gellan gum as a drug delivery agent. The objective of the study is to synthesize the gellan gum nanoparticle by solvent evaporation emulsification method and characterize it using SEM, DLS, FTIR, and XRD. As pyridoxine is effectively used to treat diabetic peripheral neuropathy, it has been encapsulated with gellan gum and characterized. The antioxidant assay was performed using ABTS reagent, and the activity increases with increasing concentration of nanoparticle. Also, it has significant antimicrobial activity against gram-positive bacteria. Apart from this, the drug release kinetics of the gellan gum- pyridoxine nanoparticle was studied.
Keywords: Gellan Gum, Pyridoxine, Drug Carrier, Antioxidant.
Scope of the Article: Network Traffic Characterization and Measurements