Molecular Modelling and in Vitro Hypoglycemic Examination of Polysubstituted Quinoline Derivatives
Gangadhara Angajala1, Valmiki Aruna2, Radhakrishnan Subashini3, Geetha Das4, Ramanathan Rajajeyaganthan5
1Gangadhara Angajala, Department of Chemistry, Kalasalingam Academy of Research and Education, Krishnankoil, Virudhunagar (Tamil Nadu), India.
2Valmiki Aruna, Department of Chemistgry, Kalasalingam Academy of Research and Education, Krishnankoil, Virudhunagar (Tamil Nadu), India.
3Radhakrishnan Subashini, Department of Chemistry, Arignar Anna Government Arts College for Women, Walajapet (Tamil Nadu), India.
4Geetha Das, Department of Chemistry, Kalasalingam Academy of Research and Education, Krishnankoil, Virudhunagar (Tamil Nadu), India.
5Ramanathan Rajajeyaganthan, Department of Chemistry, Kalasalingam Academy of Research and Education, Krishnankoil, Virudhunagar (Tamil Nadu), India.
Manuscript received on 23 November 2019 | Revised Manuscript received on 17 December 2019 | Manuscript Published on 30 December 2019 | PP: 230-233 | Volume-9 Issue-1S4 December 2019 | Retrieval Number: A11511291S419/19©BEIESP | DOI: 10.35940/ijeat.A1151.1291S419
Open Access | Editorial and Publishing Policies | Cite | Mendeley | Indexing and Abstracting
© The Authors. Blue Eyes Intelligence Engineering and Sciences Publication (BEIESP). This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Abstract: In the present work in-silico molecular simulations were carried out to find out the binding affinities of synthesized polysubstituted quinolines towards PPARγ protein (2XKW). The results obtained from docking analysis showed that the synthesized polysubstituted quinoline derivatives 1a-g are having stronger binding interactions which was on par to that of standards rosiglitazone and pioglitazone. In addition to this in-vitro hypoglycemic studies were studied through α-amylase and α-glucosidase enzyme inhibition assays. The results showed that compounds 1c and 1d possess good hypoglycemic efficacy with percentage inhibition of 87.94 ± 0.25, 85.90 ± 0.56 towards α-glucosidase and 84.55 ± 1.02, 82.14 ± 0.26 percent inhibition towards α-amylase which was greater than standard rosiglitazone and comparable to standard pioglitazone.
Keywords: Quinolines, PPARγ, Hypoglycemic.
Scope of the Article: Music Modelling and Analysis