Intraocular Pressure Model Predictive Control: A Simulation of Circadian and Mean Intraocular Pressure Control
Omer Hamid
Omer Hamid, Department of Medical Equipment Technology, College of Applied Medical Sciences, Prince Sattam Bin Abdul-Aziz University, Alkharj, Kingdom of Saudi Arabia. Alkharj, 422.
Manuscript received on 13 June 2016 | Revised Manuscript received on 20 June 2016 | Manuscript Published on 30 June 2016 | PP: 190-195 | Volume-5 Issue-5, June 2016 | Retrieval Number: E4651065516/16©BEIESP
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© The Authors. Blue Eyes Intelligence Engineering and Sciences Publication (BEIESP). This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Abstract: Pharmacokinetics/Pharmacodynamics (PK/PD) models of four ophthalmic drugs taken from the literature, employed in building model predictive control (MPC) systems. The drugs are: Latanoprost, Bunazosin, Timolol, and PF-04475270. MPC successfully controlled the mean intraocular pressure (MIOP) to a set point without overshoot or noticeable steady state error. The drug model representation order is vital in the suppression of circadian intraocular pressure variation, while the mean intraocular pressure is controllable irrespective of the model order.
Keywords: Glaucoma, Intraocular Pressure, Circadian Pattern, Model Predictive Control, Pharmacokinetics/ Pharmacodynamics.
Scope of the Article: Pattern Recognition