BIS Performance for CLAD PK-PD Model
Usharani Shola1, Neelanarayanan V2
1Usharani Shola, School of Computer Science and Engineering, Vellore Institute of Technology, Chennai (Tamil Nadu), India.
2Neelanarayana V, School of Computer Science and Engineering, Vellore Institute of Technology, Chennai (Tamil Nadu), India.
Manuscript received on 18 June 2019 | Revised Manuscript received on 25 June 2019 | Manuscript published on 30 June 2019 | PP: 837-843 | Volume-8 Issue-5, June 2019 | Retrieval Number: E7265068519/19©BEIESP
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© The Authors. Blue Eyes Intelligence Engineering and Sciences Publication (BEIESP). This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Abstract: (Please read carefully abstract of the template). Giving anesthesia in operating rooms is generally a practice of making patients unconsciousness and ensuring safe surgery to the patients. Some of the procedures are fixed, few are predefined and some need patient response to alter the anesthetic drugs infusions to reach the required hemodynamic values. The automation in drug delivery will minimize the distractions of anesthetist and he can spend more time for direct care of patient. In the view of automatic drug delivery system, developing the relationship between depth of anesthesia and the delivery of intravenous anesthetic drugs is important. This article discuss about these relationship and defined Simulink model for the same. The results are taken based on the BIS score. This score is compared with target value, the tolerance percentage levels of reaching the target value is discussed for both male and female patients.
Keywords: Closed Loop Automatic Drug Delivery System (CLADS), Depth of Anesthesia (DOA), PK-PD (Pharamacokinetic-Pharmacodynamic) Model, Sigmoid Function, Bispectral Index Scale (BIS), Simulink.
Scope of the Article: Healthcare Informatics