Synthesis of Novel and Bio-vital Pyridine based Ternary Compounds: Multi-Spectral Characterization, Biological Examination, Molecular Docking and in-Silico ADMET Profile
S. Syed Ali Fathima1, E. R. Nagarajan2
1S. Syed Ali Fathima, Department of Chemistry, Kalasalingam Academy of Research and Education, Krishnankoil (Tamil Nadu), India.
2E. R. Nagarajan, Department of Chemistry, Kalasalingam Academy of Research and Education, Krishnankoil (Tamil Nadu), India.
Manuscript received on 23 November 2019 | Revised Manuscript received on 17 December 2019 | Manuscript Published on 30 December 2019 | PP: 245-251 | Volume-9 Issue-1S4 December 2019 | Retrieval Number: A11541291S419/19©BEIESP | DOI: 10.35940/ijeat.A1154.1291S419
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© The Authors. Blue Eyes Intelligence Engineering and Sciences Publication (BEIESP). This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Abstract: The novel bio-crucial ternary compounds were synthesized and characterized by several spectral techniques and other physicochemical analysis. From all the measurements, octahedral structure was proposed for all the synthesized compounds. Moreover, the synthesized compounds have driven for their biological outlook. The DNA synergy was achieved by UV-studies displayed that the prepared complexes may interact with nucleic acid through intercalated pathway. In addition, the antimicrobial analysis of synthesized compounds explicated the compounds were best antibiotics against selected microbes. The gel electrolysis study showed that the major DNA bifurcation activity of the complexes to separate the pUC 18 nucleic acid fragment. The in-vitro antiproliferative activity of the complexes is investigated on breast and liver tumour cell panel confirmed that the metal complexes have considerable metastatic tumour ability. The antioxidising report evident that the metal complexes carry the attractive talent to chase the radical correlated to ligand. The drug-like evaluations exposed that the mixed ligand complexes possess substantial drug-like efficiency based on Lipinski’s set of laws. Ultimately, the docking simulations are validated to realize the binding mode of the ternary compounds with FGFR protein and 1BNA.
Keywords: Antibiotics, Biological Outlook, Drug-like Efficiency, Mixed Ligand Complex.
Scope of the Article: Bio-Science and Bio-Technology