Separation of Ketoprofen Racemate by TLC Plate with Different Chiral Selectors
D. Gherdaoui1, H. Bekdouche2, R. Fegas3, A. Zeghdaoui4, F. Bouazza5, S. Zerkout6
1D. Gherdaoui, Department of Chemistry, Normal Superior School, Kouba, Algiers, Algeria.
2H. Bekdouche, Department of Chemistry, Normal Superior School, Kouba, Algiers, Algeria.
3R. Fegas, Department of Chemistry, Normal Superior School, Kouba, Algiers, Algeria.
4A. Zeghdaoui, Department of Chemistry, Normal Superior School, Kouba, Algiers, Algeria.
5F. Bouazza, Department of Chemistry, Normal Superior School, Kouba, Algiers, Algeria.
6S. Zerkout, Department of Chemistry, Normal Superior School, Kouba, Algiers, Algeria.
Manuscript received on September 24, 2013. | Revised Manuscript received on October 19, 2013. | Manuscript published on October 30, 2013. | PP: 181-182 | Volume-3, Issue-1, October 2013. | Retrieval Number: A2187103113/2013©BEIESP
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© The Authors. Blue Eyes Intelligence Engineering and Sciences Publication (BEIESP). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Abstract: Separation of enantiomers has become a well-established technique in many fields of science; it is a matter of great importance in pharmaceutical, chemical and biotechnology. In fact, the biological and pharmacological activity of chiral compounds depend on their configuration; one of the enantiomers is pharmacologically active and even can be toxic. It is thus desirable to have reagents and separation techniques to separate the enantiomers and analyze the enantiomeric purity. A variety of chromatographic methods have been developed for optical resolution recently. Direct and simple separation of the enantiomers of ketoprofen is carried out on TLC plate used different chiral selectors in the mobile phase such as: quinidine, quinine carbamate, vancomycin and cyclodixtrin. The success of enantioseparation of racemic ketoprofen is due to the difference in characteristics and selectivity of each selector.
Keywords: Chiral Selector, Enantioseparation, ketoprofen, TLC.