Deuteration as a Tool for Enhancing the Half-Life of Drug
Vijay Kumar1, Archana Dhyani2, N. Singh3
1Vijay Kumar, Department of Physics, Graphic Era Hill University, Clement Town, Dehradun (Uttarakhand), India.
2Archana Dhyani, Department of Pharmacy, Graphic Era Hill University, Clement Town, Dehradun (Uttarakhand), India.
3N.Singh, Department of Pharmacy, Graphic Era Hill University, Clement Town, Dehradun (Uttarakhand), India.
Manuscript received on 27 April 2019 | Revised Manuscript received on 09 May 2019 | Manuscript Published on 18 May 2019 | PP: 19-20 | Volume-8 Issue-6S4 November 2019 | Retrieval Number: F10091186S419/19©BEIESP | DOI: 10.35940/ijeat.F1009.1186S419
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© The Authors. Blue Eyes Intelligence Engineering and Sciences Publication (BEIESP). This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Abstract: The aim of the article is that deuteration of any compounds leads to the enhancement of metabolic activity. The substitution of Carbon-Hydrogen bond by Carbon –Deutrieum help for enhancing pharmacokinetic profile of the drug. Since C-D bond is ten time more tough to C-H bond .Nowadays, many drug molecules are deuterated to increase the residence time of the drug as well as diminution the metabolism of the drug. Deuterated drugs also finds various therapeutic applications. The deuterated drugs is also approved by Food and Drug Administration. The deuteration helps in increasing the dwell time of the drug and reducing frequency of dosing.
Keywords: Deuteration, Half- Life, Pharmacokinetics, Therapeutic Effects.
Scope of the Article: Bio-Science and Bio-Technology