Intellectual Acute Lymphoblastic Leukemia (ALL) Detection Model for Diagnosis of Blood Cancer from microscopic images using Hybrid Convolutional Neural Network
Anuj Sharma1, Bala Buksh2
1Mr. Anuj Sharma Ph. D from Career Point University, Kota (Rajasthan).
2Dr. Bala Buksh , Ph. D. (Comp. Sc.) – Birmingham, United Kingdom.
Manuscript received on August 03, 2019. | Revised Manuscript received on August 22, 2019. | Manuscript published on August 30, 2019. | PP: 2972-2981 | Volume-8 Issue-6, August 2019. | Retrieval Number: F9001088619/2019©BEIESP| DOI: 10.35940/ijeat.F9001.088619
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© The Authors. Blue Eyes Intelligence Engineering and Sciences Publication (BEIESP). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Abstract: Blood cell malignantly growth has been accounted for to be one of the most transcendent types of disease maladies. ALL (Acute Lymphoblastic Leukaemias) is the malignant types of blood cancer and their detection and classification in earlier stage is biggest issue. Automatic detection and classification of ALL from microscopic images is a challenging and intellectual assignment in medical science. Existing techniques for ALL detection and classification are an understandable alternative for real-time dermoscopic data analysis. Existing microscopic image processing approaches are unable to analyze the ALL data with non-stationary nature. In this perspective, the focus of this research is to design hybrid Convolutional Neural Network (CNN) architecture by utilizing Firefly Optimization Algorithm (FOA/FFA) to detect the ALL from microscopic images of human blood cell into malignant or normal blood cell. Methods: For training and testing of proposed ALL Detection and Classification (ALL-DC) Model, Standard ALL-IDB (Acute-Lymphoblastic-Leukaemias Image Database for Image Processing) is used with hybrid CNN architecture based on the FOA. Here, Histogram of Oriented Gradients (HOG) descriptor with FOA is used as feature extraction and selection mechanism from the Region of Blood Cell (ROBC).Feature extraction approach plays an important responsibility to classify lots of blood diseases. On the way to achieve this goal, we proposed ALL-DC model that combines recent developments in deep learning with fuzzy based CNN structure and for ROBC segmentation, hybridization of K-means segmentation algorithm with FOA that are capable to segment the accurate blood cell region from microscopic images. Using k-means segmentation technique, the foreground and background component is separated into two regions and after that to improve the segmentation results; FOA is used with the novel concept of image enhancement approach. Results: The proposed ALL-DC system is evaluated using the largest publicly accessible standard ALL-IDB dataset, containing 600 training and 400 testing microscopic images. When the evaluation parameters of proposed work is compared with a number of other state-of-art schemes, the proposed scheme achieves the most excellent performance of 98.5% in terms of accuracy which also known as area under the curve (AUC) in differentiating ALL from benign cell using only the extracted and optimized HOG feature. Conclusion: When the proposed model is tested on different microscopic images, evaluation parameters is calculated and compared with a few other state-of-art methods and we obtained the proposed method achieves the best performance in terms of classification accuracy. ALL-DC model is implemented and constructed using the concept of Image Processing and Neural Network Toolbox within MATLAB Software.
Keywords: ALL Detection and Classification Model-means, Histogram of Oriented Gradients Descriptor, Firefly Optimization Algorithm, Fuzzy Logic, Convolutional Neural Network.